The effect of Plastic Orchechtomy on Alteration of Lipid Metabolism and General Condition of the Body

Prostate cancer is one of the most common cancers in men. Therefore, fundamental research of the mechanisms of prostate carcinogenesis, study of energy metabolism alterations during malignant transformation and searching for the novel prostate specific biomarkers will bring significant novelty in the existing knowledge about prostate tumor transformation and progression. It is known that the development of a malignant prostate tumor proceeds with a significant disorder of lipid metabolism. Lipids and their metabolites play an important role in the processes of cell proliferation and malignancy. Based on this, the aim of our research was to study the influence of plastic orchiectomy on alteration in blood lipid metabolism and the general condition of the body. Our investigations have shown that after plastic orchiectomy inhibition of lipid peroxidation in the blood, decreased levels of cholesterol and phospholipids (amino and choline-containing lipids) that were close to control group indices, is an indicator of regression of the tumor process for the certain period; Also, another evidence for the tumor process regression is reduced level of PSA in the blood and decreased activity of acid phosphatase, as the prostate-specific tumor marker. It has been confirmed that despite surgical intervention, there has not been an absolute recovery of patients after plastic orchiectomy. However, the normalization of several indicators at this stage of the postoperative period (6-18 months) indicates a relative strengthening of the body's immune system and, consequently, an improvement in defenses.