Prevention of multiple sclerosis with creatine and flavonoids

Author: Temuri Mantashashvili
Keywords: multiple sclerosis, creatine, flavonoids, oxidative stress, demyelination, myelin sheath, neurodegeneration, antioxidant
Annotation:

In recent years, a disease such as multiple sclerosis (MS) has become increasingly popular. This disease begins with changes in complex molecular mechanisms in the nervous tissue, followed by damage to the myelin sheath - neurodegeneration. This disease is based on an autoimmune reaction, as a result of which the myelin sheath covering the axons is perceived as foreign by the body and destroyed by the cells of the immune system. About 1100 cases are recorded in Georgia. It is noteworthy that the cases have increased significantly in the recent period. This may be related to the fact that today in modern medicine diagnostic methods have been improved and the detection of diseases has become easier. However, we cannot deny that worsening environmental conditions and increased stress play an important role in the spread of this serious disease. Various scientific studies have established that multiple sclerosis can be prevented by reducing the oxidative status of cells, by strengthening the antioxidant system. To strengthen the mentioned systems, it is important to find such biologically active compounds that will perform a certain protective function, among which are the nitrogenous compound creatine involved in the transport and storage of high-energy phosphates in the cell and compounds with antioxidant properties - flavonoids. It was found that the mentioned compounds significantly reduced the development of the mechanisms that contribute to the development of the disease, and alleviated the symptoms in diseased models. The aim of this work is to raise public awareness of multiple sclerosis and prevention methods.