Study of genomic parameters in elderly individuals by influance of peptide bioregulator

The course of all stages of ontogenesis, including the aging process, is subject to epigenetic regulation, which is reflected in the subsequent variation of genomic parameters. If in the early stage of development, the change in the state of chromatin ensures normal development, in the later stage of ontogenesis it is associated with a violation of cellular and organismal homeostasis - a decrease in the immune status and level of repair, which leads to a gradual loss of body functions and the development of aging pathologies. It is known that compaction-decompactization of chromatin caused by methylation (heterochromatinization-deheterochromatinization) is the epigenetic regulator of gene expression, which is responsible for turning genes off and on, because the accessibility of genes to the transcription apparatus depends on these processes. Genomic parameters changed during the aging process are subject to correction under certain conditions. In this regard, it is appropriate to study geroprotectors - regulatory oligopeptides used in geriatric practice to reduce the intensity of aging processes and prevent aging pathologies. In this regard, special attention is drawn to the study of a new generation of geroprotector drug - thymalin. The drug, which is a synthetic analog of the regulatory peptide present in the thymus, is used to increase immunity. It is known that with increasing age, there is a significant decrease in the size of the thymus and, accordingly, a decrease in the number of its hormones, which affects the body's immune index, therefore, the study of the influence of thymalin on the normalization of genomic parameters changed in the aging process is of particular interest. Based on this, the aim of this work was to study the regulatory action of the peptide bioregulator - thymalin on the changed genomic characteristics of elderly individuals and its influence on the activity of synthetic processes. Analysis of the results showed that thymalin does not affect the disturbed genomic parameters, however, it significantly increases the activity of ribosomal cistrons and the frequency of acrocentric chromosome associations, which indicates an increase in the activity of synthetic processes during the action of the mentioned bioregulator.