Functional changes of glutamatergic receptors in some areas of the brain under chronic stress

Author: Natia Guliashvili
Keywords: stress, social isolation, cerebral cortex, hippocampus, cortisol, glutamate, receptor, glutamatergic system, glutamate receptors, NMDA receptor, AMPA receptor, enzyme Na+/K-ATPase
Annotation:

Long-term social isolation is a significant stressor for living organisms. It is known that during chronic stress caused by long-term social isolation, there is a change in the activity of the glutamatergic system. We studied the quantitative changes of glutamate NMDA- and AMPA-receptor subunits and their phosphorylated forms in the hippocampus and cortex of the brain of experimental animals under the conditions of long-term 30-day social isolation. It was shown that, under the conditions of activation of glutamate receptors, the activity of the enzyme Na+/Ka+-ATPase in the cells of the hippocampus and cortex of the brain also changes. However, different activation levels of glutamate receptors are observed in these two brain regions. Along with the receptors, the level of activation of the enzyme Na+/Ka+-ATPase in the cells of this area is also different.