SEPARATION OF ENANTIOMERS OF SOME CATHIONIC CHIRAL DRUGS WITH NEUTRAL CYCLODEXTRINS

Author: Ani Rurua
Co-authors: Mariam Shanidze
Annotation:

In the present study CE was used for separation of enantiomers of cationic chiral drugs, such as brompheniramine and dimethindene with β-CD and its derivative, heptakis-(2,3,6-tri-O-methyl)-β-CD (TM-β-CD). Separation of enantiomers was performed in fused-silica capillary of 50 µm ID and 24 and 32.5 cm, effective and total lengths, respectively. The background electrolyte was 100 mM triethanolamine phosphate with pH=3.0. Various concentrations of cyclodextrins (CD) were used having in mind using CE for determination of selector-selectand association constants. The most interesting result of this study was that the enantiomers of all 4 analytes exhibited opposite affinity pattern towards studied β-CD and TM-β-CD.

Lecture files:

SEPARATION OF ENANTIOMERS OF SOME CATHIONIC CHIRAL DRUGS WITH NEUTRAL CYCLODEXTRINS [en]
ზოგიერთი კათიონური ქირალური სამკურნალწამლო საშუალების ენანტიომერების დაყოფა ნეიტრალური ციკლოდექსტრინების გამოყენებით [ka]