Study of the Compliance of Some Medicinal Forms of Lansoprazole with International Standards

Author: Tornike Sarjveladze
Keywords: Lansoprazole, Enantiomers, Liquid chromatography
Annotation:

The enantioseparation of chiral drugs and the control of enantiomeric purity are important for different fields of chemistry, especially in the pharmaceutical area, as the enantiomers commonly have different pharmacological and toxic properties. One of the main techniques for separation of enantiomeric mixtures is high-performance liquid chromatography, and the most widely used chiral stationary phases in this method are amylose and cellulose phenylcarbamates. Their use to separate enantiomeric mixtures can be carried out using aqueous solutions of polar-organic and organic solvents. Lansoprazole is a chiral drug for treatment of ulcerative diseases of the stomach and duodenum, a specific inhibitor of H+-K+ -ATP-az. Lansoprazole blocks the latter stage of hydrochloric acid synthesis and reduces the basal and stimulated secretion of juice, has a cytoprotecal effect and increases the secretion of bicarbonates. Therefore, the main purpose of the present master's thesis was to separate the enantiomers of Lansoprazole as a chiral drug using polysaccharide-based chiral stationary phases and organic solvents. The developed method was validated and used for studying the compliance of some lansoprazole-formulations with international standards.