Synthesis of 9-iodo-6H-indolo[2,3-b]quinoxaline arylamino derivatives by Ullmann reaction

Author: Tornike Kotua
Keywords: 9-iodo-6H-indolo[2, 3-b]quinoxsaline, Ullmann reaction, DNA intercalator, 6-benzyl-N-phenyl-6H-indolo[2, 3-b]quinoxsaline-9-amine
Annotation:

The reactivity of 9-iodo-6H-indolo[2,3-b]quinoxsaline and its N-benzyl derivative in the copper-catalyzed Ullmann reaction was studied. By condensation of 5-iodoindoline-2,3-dione and benzene-1,2-diamine the key product 9-iodo-6H-indolo[2,3-b]quinoxsaline was synthesized. By reacting this system with benzyl chloride in the superbase, 6-benzyl-9-iodo-6H-indolo[2,3-b]quinoxsaline was obtained. By the reaction between benzylamine and 6-benzyl-9-iodo-6H-indolo[2,3-b]quinoxsaline in the presence of the catalyst CuI, in DMF, the target heterocyclic system 6-benzyl-N-phenyl-6H-indolo[2,3-b]quinoxsaline-9-amine was synthesized.

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Abstract [en]
ანოტაცია [ka]