Study of release process of chlorpromazine from microemulsions

Author: Eto Derevianchenko
Keywords: Oil-in-water microemulsions; chlorpromazine; drug release; diffusion exponent; kinetic constant
Annotation:

Chlorpromazine (CPZ) is a widely used drug. It is a surface-active micelle-forming compound, and it is characterized by presystem metabolism. Therefore, the drug delivery system is useful for transporting the accumulated drug in the body. The release profile of CPZ from oil-in-water microemulsions prepared on the basis of nonionic polymer-type surfactants tyloxapol and pluronic was studied. An optimal method for determination of CPZ in the receptor solution using blood red salt, ferric (III) chloride and acetic acid has been developed. Optical density of the obtained colored solution was measured at 670 nm. The weight percent of CPZ release from dialysis bags was found to be significantly less from tyloxapol and pluronic microemulsions than in case of pure water.