Electromagnetic resonance (EPR) and nuclear magnetic resonance (NMR) methods and applications in living systems

Author: Nika Natsvlishvili
Keywords: EPR spectroscopy, Electron paramagnetic resonance, Electron spin resonance, Paramagnetism, Unpaired electrons, Zeeman effect, NMR spectroscopy, Nuclear magnetic resonance, Nuclear spin
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Electromagnetic resonance (EPR) and nuclear magnetic resonance (NMR) methods are widely used in biological and medical research to study living systems at the molecular level. The relevance of these techniques lies in their ability to provide valuable information about the structure, dynamics, and functions of biomolecules. The goals of EPR and NMR research in living systems include understanding the interactions between molecules, investigating molecular conformational changes, and elucidating the mechanisms of biological processes. These methods allow scientists to investigate the behavior of biomolecules in their native environment, providing crucial information for drug discovery, disease diagnosis, and the development of therapeutic interventions. The objects of EPR and NMR studies include a wide range of biological molecules, such as proteins, nucleic acids, carbohydrates, and lipids. Using these techniques, researchers can obtain detailed information about molecular interactions, enzymatic reactions, membrane dynamics, and cellular signaling pathways. The main results achieved by EPR and NMR studies in living systems include the determination of high-resolution structures of biomolecules, the identification of binding sites and ligand interactions, the characterization of protein-protein and protein-DNA interactions, and the study of protein dynamics under various physiological conditions. In essence, the use of EPR and NMR techniques is of great importance in improving our understanding of living systems. These methods provide comprehensive insights into the structure and behavior of biomolecules, thereby contributing to the advancement of biological and medical research. They have greatly contributed to our understanding of biological and medical research, offering valuable discoveries, and current advances are continually increasing the potential of these methods for future research.