Synthesis of 9-iodo-6H-indolo[2,3-b]quinoxaline and its transformations

Author: Ana Chabrava
Co-authors: Professor Ioseb Chikvaidze
Keywords: 9-iodo-6H-indolo[2, 3-b]quinoxaline, Cross-coupling, terminal alkynes
Annotation:

There are synthesized 9-iodo-6H-indolo[2,3-b]quinoxaline and its N-benzyl products . Their properties in the metal-catalyzed Sonogashira cross-coupling reaction, the interaction of existing halogen products with terminal alkynes such as phenylacetylene, propargylamine and trimethylsilylacetylene are studied. The reaction takes place in the presence of PdCl2(PPh3)2 and CuI cocatalyst in dimethylformamide (DMF) in the base (Et3N). Four new substances were obtained: 9-(phenylethynyl)-6H-indolo[2,3-b]quinoxaline, 9-((trimethylsilyl)ethynyl)-6H-indolo[2,3-b]quinoxaline, 6-benzyl-9-( phenylethynyl)-6H-indolo[2,3-b]quinoxaline and 3-((6H-indolo[2,3-b]quinoxalin-9-yl)ethynyl)aniline.

Lecture files:

Synthesis_of_9-iodo-6H-indolo[2,3-b]quinoxaline and its transformations [en]
9-იოდ-6H-ინდოლო[2,3-b]ქინოქსალინის სინთეზი და მისი გარდაქმნები [ka]